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Table 2. Selection of Detroit 562 genes induced in response to M. catarrhalis BBH18.

a FC; fold-change BBH18-infected/mock-infected Detroit

Enhanced gene expression was observed for various transcriptional regulators and components of signal transduction pathways such as the transcription activator JUN, and the cyclic AMP-dependent transcription factor ATF-3. In addition, increased expression of immune dampening factors was found for the NF-κB pathway suppressors IκB-α (NFKBIA), acting in the cytoplasm to sequester NF-κB, and the kinase MAP3K8 [ 41 ]. The panel of immune suppressors was extended by increased expression of TNFAIP3, which functions in a negative feedback loop regulating TLR-ligand and TNF induced responses [ front closure bikini top Multicolour Fleur du Mal Free Shipping Manchester Cheap Limited Edition LkfZSZMzr

Noteworthy, M. catarrhalis binding induced expression of α-1-antichymotrypsin (SERPINA3), a serine protease inhibitor that protects host tissue from oxidative and proteolytic damage [ 46 ] in order to counteract the action of neutrophil secreted factors such as elastase, metalloproteases and reactive oxidative radicals. Previously it was proposed that UspA-mediated α-1-antichymotrypsin binding by M. catarrhalis confers resistance against host proteases. This potentially allows M. catarrhalis to induce more severe inflammation, which may result in excessive tissue damage and subsequently exposure of ECM that facilitates bacterial attachment and colonization [ 8 , 46 ]. Of note, upon binding of M. catarrhalis expression of anti-apoptotic genes BCL2A1 and BIRC3 was also increased, potentially compensating for apoptotic stimuli and preventing damage to the epithelial barrier ( Table 2 ).

Overall, the abundantly induced inflammatory response characterizing M. catarrhalis airway inflammation is key to infiltration of neutrophils, lymphocytes, and macrophages, and contributes to COPD exacerbation and OM pathogenesis [ 8 , 47 ]. The potential of M. catarrhalis to induce high levels of inflammation may cause higher disease burden during co-infection with other respiratory tract pathogens such as S. pneumoniae and NTHi. For S. pneumoniae , a pro-inflammatory environment has been shown to be required for progression to the middle ear and its ability to cause OM, exemplified by Short et al. who demonstrated that viral or lipopolysaccharide-induced inflammation is sufficient for S. pneumoniae to cause OM in an infant murine model [ 48 ]. Interestingly, co-infection of M. catarrhalis with S. pneumoniae resulted in increased incidence of OM, higher pneumococcal load, and prolonged infection in a murine nasopharyngeal colonization model [ 49 ].

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Durante el propio Google I/O, la gran G manifestó su interés por hacer de Android un sistema abierto mientras restringía lo mejor de Android a unos pocos.
11/05/2018 a las 21:03 UTC
En: Google I/O

Durante esta semana se ha celebrado el Google I/O, uno de los eventos más importantes para desarrolladores. Siendo Android uno de los productos de mayor éxito de Google esperábamos novedades, y vaya que si las ha habido.

Más allá de las mejoras de Google Assistant (que por cierto, dan miedo) o las interesantes novedades que llegarán a Google Maps y Fotos , creo que la segunda versión de Android P fue la verdadera protagonista del evento. Y no, no hablamos de las novedades de esta nueva versión para desarrolladores, sino de algo mucho más grande.

Con la primera versión de Android P dimos el adiós definitivo a los Nexus de Google. Esta marca ha representado durante años lo mejor de lo mejor en Android.

Hagamos memoria, y es que hasta el lanzamiento del primer Google Pixel; en 2016; la gran G nunca fue un fabricante de teléfonos móviles. Sí que tenía una marca llamada Nexus. Nexus no solo era la marca en la que Google presentaba cada nueva versión de Android, también era un acuerdo con los distintos fabricantes con los que Google ha decidido asociarse.

era un acuerdo con los distintos fabricantes con los que Google ha decidido asociarse.

Esta es la primera versión de Android en la que suponíamos que estarían solo los Pixel en el escenario, solo móviles de Google. Y nos equivocamos, ya que en el momento de la verdad vimos el anuncio de todos los móviles que recibirían la segunda versión para desarrolladores de Android P. Xiaomi, Essential, Sony, Nokia, Oppo y OnePlus compartían escenario con Google.

Ayer mismo mi compañero Álvarez del Vayo hablaba de esto desde otro punto de vista. Si lo que a mi me impactó es que Google se rodease de amigos, lo que a Fernando más le impactó es que en la lista de fabricantes que tendrían prioridad para Android P no figuraban los más importantes a día de hoy, o al menos los que más venden. Hablamos de Samsung y Huawei.

Lo cierto es que Samsung siempre ha ido un poco por su propio camino. En alguna ocasión han intentado hacer las cosas a su manera, primero con Bada y ahora con Tizen. Si bien en móviles siempre han acabado volviendo a Android, en relojes inteligentes no temen en tener el máximo control del hardware y software . E incluso dentro de Android, su capa de personalización siempre ha tirado más a ofrecer la visión que la compañía considera más apropiada. Y claro, los resultados acompañan para bien.

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Controlling Trace Organic Contaminants Using Alternative, Non-FAT Technology for Indirect Potable Water Reuse

Posted: May 23, 2017

The project will investigate the advanced treatment of wastewater for indirect potable reuse (IPR) using ion exchange (IX), advanced oxidation processes (AOPs) and biofiltration as an alternative to the fully available treatment (FAT) technology of reverse osmosis (RO) and UV AOPs.

Posted: January 17, 2017

The project will develop a standard operations and maintenance plan for various DPR treatment processes, including appropriate portions of the upstream secondary wastewater treatment processes providing feedwater to the DPR processes…

Management of Legionella in Water Reclamation Systems

Project: 12-05 Estimated Release: 2015 Type: Report

Project: Estimated Release:

Program: Principal Funding Partner: Singapore PUB Total Budget: $355,164 (Cash: $200,000, In-Kind cash and service: $155,164)

Program: Funding Partner: Total Budget:

Principal Investigator: Mark LeChevallier, American Water

Principal Investigator:

Members of the genus Legionella are common inhabitants of potable water distribution systems, often proliferating in biofilms and in the presence of free-living protozoa. In WateReuse Research Foundation projects Guidance Document on the Microbiological Quality and Biostability of Reclaimed Water Following Storage and Distribution (WateReuse-05-002 published 2010) and Approaches to Maintain Consistently High Quality Reclaimed Water in Storage and Distribution Systems (WateReuse-08-04 expected publication date March 2012), Legionella were observed in recycled water distribution systems. Growth was attributed to the rapid loss of the disinfectant residual in recycled water and was associated with nutrient levels, particularly BDOC. However, these and other studies have not discerned the incidence of the Legionella serogroups that are pathogenic to humans, or determined the significance of pathogenic serogroups in water systems and end user sites. Recycled water uses such as spray landscape irrigation, water features (e.g. decorative fountains), cooling towers, and other public access uses can aerosolize water. Therefore, it is important to understand the role of Legionella transport in water droplets because inhalation of pathogenic Legionella spp. attached to water aerosols is the primary route of infection.

Despite the ubiquitous nature of Legionella in water, the public health importance of water-associated Legionella in drinking water and recycled water is not known. In order to ensure that that risk is minimized and to further build public confidence for using recycled water for these applications, it is important that the WateReuse Research Foundation investigate the incidence, relative risk (compared to drinking water), and develop management recommendations for the end users of recycled water. While L. pneumophila Serogroup 1 is an important human pathogen, the occurrence of this species and Serogroup versus other members of the genus and species in recycled water distribution systems is unknown. The effects of recycled water quality parameters on the growth (emphasis added), survival, and susceptibility of Legionella in distribution systems are also unknown. Data on the occurrence, survival, and disinfection susceptibility of Legionella spp in recycled water distribution systems are needed in order to formulate strategies for Legionella control in these systems.

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